4-Hydroxythiobenzamide, also known as p-hydroxythiobenzamide, is an off-white to light yellow solid powder at room temperature. It contains a thiocarboxamide group (-C(=S)-NH₂) and a phenolic hydroxyl group (-OH), with good stability, and is mainly used as a pharmaceutical intermediate.
Physical & Chemical Properties
Molecular FormulaC7H7NOS
Density:1.338±0.06g/cm³g/cm³
Boiling Point:320.4±44.0℃
Solubility:
Slightly soluble in DMSO and methanol; insoluble in water.
Molecular Weight:153.20g/mol
Flash Point:
Melting Point:181–185℃
Uses
1. Core application: Key intermediate for Febuxostat (used in the synthesis of anti-gout drugs).
2. Organic synthesis: Building block for thioamides, raw material for heterocyclic synthesis.
3. Pharmaceutical & chemical industry: Drug molecule modification, synthesis of sulfur-containing compounds