Niacinamide is the active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.
Physical & Chemical Properties
Molecular FormulaC6H6N2O
Density:1.4g/cm³g/cm³
Boiling Point:150-160℃
Solubility:Freely soluble in water and ethanol, soluble in glycerol, insoluble in diethyl ether, benzene and other organic solvents.
Molecular Weight:122.1g/mol
Flash Point: 182℃
Melting Point:127-131℃
Uses
1. Pharmaceutical field:Used for the prevention and treatment of nicotinic acid deficiency diseases such as pellagra. It participates in the synthesis of coenzymes I and II in the body and maintains the health of the skin and digestive system.
2. Food / Feed additive:Used as a nutritional fortifier in food and feed to supplement vitamin B3.
3. Cosmetic industry:With effects of whitening, oil control and skin barrier repair, it is widely used in skin care formulations.
4. Chemical raw material:Used in the synthesis of other pharmaceutical and chemical intermediates.
Safety, Security & Risk
Physical Hazards
When in the form of powder or particles mixed with air, it may cause a dust explosion.
Chemical Hazards
When burned, it produces toxic gases containing nitrogen oxides.Reacts with oxidizing agents.